This was from a year ago but seemed like decent feedback and I wondered if it sounds familiar or had been resolved:
“Speckle also creates some guid trouble when we ran several scripts in the same file. Also every time we closed and opened it the amount of output nodes in gh doubled.”
https://www.reddit.com/r/rhino/comments/c2s3ny/anybody_here_using_speckle_to_bridge_grasshopper/
Sounded like a pretty nasty issue so I thought I’d report it!